NMN (β-Nicotinamide mononucleotide) for Hair Loss and Growth: A Comprehensive Guide
As a doctor at My Hair UK, I often encounter patients concerned about hair loss and seeking effective solutions for regrowth. One promising avenue of research has emerged around a compound known as β-Nicotinamide mononucleotide (NMN). Traditionally recognized for its anti-aging properties and potential benefits in treating conditions like Alzheimer’s disease, NMN is gaining attention in the context of hair health. This article will delve into the connection between NMN and hair regrowth, exploring its mechanisms, benefits, potential side effects, and alternatives. Even Andrew Huberman, the esteemed health podcaster and professor at Stanford University and someone highly respected by all at My Hair UK for his work in spreading free healthcare advice, recently noted that he is taking NMN suppliments daily and has seen a dramatic increase in hair growth speed.
Understanding NMN and Its Role in Hair Health
What is NMN?
Nicotinamide mononucleotide (NMN) is a nucleotide derived from ribose and nicotinamide. It serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in the body involved in various metabolic processes, including energy production, DNA repair, and cellular aging. Your body effectively uses NMN to make NAD as it cannot absorb NAD orally. You will probably remember from school science lessons being taught that "mitochondria are the powerhouse of the cell" and increased levels of NAD helps boost their energy production. As we age, levels of NAD+ decline, leading to various health issues, including those related to hair loss.
The Connection Between NMN and Hair Growth
Recent studies have highlighted NMN's potential to influence hair growth positively. Research has indicated that NMN can combat hair follicle atrophy, hair thinning, and hair sparsity, particularly in conditions induced by dihydrotestosterone (DHT), a hormone closely linked to androgenetic alopecia (AGA) or male pattern baldness.
In animal studies, NMN administration has shown a capacity to stimulate hair regrowth in depilated mice, suggesting that NMN may be an effective treatment option for hair loss. Furthermore, NMN has demonstrated the ability to promote the proliferation of human dermal papilla cells (HDPCs), which are crucial for hair follicle health.
How NMN Promotes Hair Growth
Regulating Hair Follicle Activity
NMN influences the hair growth cycle by enhancing the function of HDPCs, which play a significant role in regulating hair follicle activity. In vitro studies reveal that NMN can protect HDPCs from oxidative stress and inflammatory damage caused by DHT. This protective effect helps maintain the viability of hair follicles, promoting healthier hair growth.
Reducing Inflammation
Inflammation is a significant contributor to hair loss. NMN has been shown to inhibit the release of inflammatory mediators such as interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and tumor necrosis factor-alpha (TNF-α) in HDPCs treated with DHT. By reducing inflammation, NMN helps create a healthier environment for hair follicles, fostering optimal conditions for growth.
Enhancing Blood Flow
Another essential aspect of NMN's role in hair health is its potential to promote angiogenesis, the formation of new blood vessels. This process increases blood flow to the hair follicles, providing them with the necessary nutrients and oxygen for robust growth. Improved blood circulation ensures that hair follicles receive an adequate supply of growth factors, such as vascular endothelial growth factor (VEGF), which is crucial for hair regeneration.
Combating Oxidative Stress
Oxidative stress, caused by an imbalance between free radicals and antioxidants in the body, can lead to cellular damage and hair loss. NMN exhibits antioxidant properties that can reduce oxidative stress levels, further protecting HDPCs from damage and promoting hair growth.
Reducing Grey Hair
Anecdotal evidence is also frequently being reported online of NMN causing hair follicles to regain some of their colour, with people reporting a darkening of hair and hairs turning from grey back to their original hair colour after extended use. No scientific studies have yet been carried out to corraborate this yet.
Clinical Evidence Supporting NMN for Hair Regrowth
Animal Studies
Animal studies involving mice have shown promising results regarding NMN's ability to induce hair regrowth. In one study, NMN treatment reversed hair follicle atrophy and improved hair density in DHT-induced models. These findings indicate that NMN may be an effective therapeutic option for combating androgenetic alopecia.
Human Trials
While human trials are still limited, preliminary research suggests that NMN could benefit hair health. For example, studies have indicated that NMN enhances the proliferation of HDPCs, which are essential for maintaining healthy hair follicles. Further research is necessary to establish definitive conclusions about its efficacy in humans.
How to Incorporate NMN into Your Hair Care Routine
If you are considering incorporating NMN into your hair care regimen, here are some tips to maximize its benefits
Get The Right Dosage
Whilst anecdotal, 1500mg NMN powder taken daily in the morning sublingually (allowed to dissolve under the tongue) is being used by Andrew Huberman and is recommended online.
Choose Quality Supplements
When selecting NMN supplements, it is crucial to opt for high-quality products from reputable manufacturers. Look for supplements that contain pure NMN without unnecessary fillers or additives.
Combine with a Healthy Diet
A balanced diet rich in vitamins, minerals, and antioxidants can complement the effects of NMN. Foods high in vitamins C and E, omega-3 fatty acids, and proteins can enhance hair health and support NMN's actions.
Maintain a Consistent Routine
To see potential benefits from NMN, consistency is key. Incorporate NMN supplements into your daily routine and maintain a healthy diet for optimal results.
Consult a Professional
Before starting any new supplement regimen, it is always advisable to consult a healthcare professional. They can guide you on appropriate dosages and any potential interactions with existing medications.
Potential Side Effects of NMN
Generally Safe, but Individual Reactions May Vary
NMN is generally considered safe for most individuals. However, some may experience mild side effects, including gastrointestinal discomfort, nausea, or headaches. As with any supplement, individual reactions can vary, so it’s essential to monitor your body’s response and consult with a healthcare provider if you experience adverse effects.
Allergies and Interactions
Since NMN is often derived from natural sources, individuals with allergies to specific plants or ingredients should exercise caution. Additionally, NMN may interact with certain medications, so it’s crucial to discuss any potential interactions with your healthcare provider.
Proven Alternatives to NMN for Hair Growth
While NMN shows promise, several other proven treatments can help combat hair loss and promote regrowth and NMN can be combined with any of these safely:
Minoxidil
Minoxidil is a widely used topical treatment for hair loss that increases blood flow to hair follicles, encouraging hair regrowth. It is available over the counter and is effective for both men and women.
Finasteride
Finasteride is an oral or topical medication that inhibits the conversion of testosterone to DHT, the hormone responsible for hair loss in androgenetic alopecia. It is particularly effective in men but is not typically recommended orally for women due to potential side effects.
Hair Transplant Surgery
For individuals seeking a long-term solution for hair loss, hair transplant surgery may be the best option. This procedure involves relocating healthy hair follicles from areas of the scalp with sufficient hair growth to balding or thinning areas, providing a permanent solution to hair loss. With a typical hair transplant cost almost halving in the last 10 years it has now become a more affordable everyday solution for many.
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Low-Level Laser Therapy (LLLT)
LLLT is a non-invasive treatment that uses laser light to stimulate hair follicles and improve hair density. It has shown promising results in clinical trials and can be a valuable addition to hair restoration efforts.
FAQs About NMN and Hair Loss
What is NMN?
NMN, or β-Nicotinamide mononucleotide, is a compound that serves as a precursor to nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in various cellular processes, including energy metabolism and DNA repair.
How does NMN promote hair growth?
NMN promotes hair growth by enhancing HDPC proliferation, reducing inflammation, increasing blood flow to hair follicles, and combating oxidative stress.
Are there any side effects of taking NMN?
NMN is generally considered safe for most individuals, but some may experience mild gastrointestinal discomfort or headaches. It is essential to consult a healthcare provider if you have concerns.
Can I take NMN with other hair loss treatments?
Yes, NMN can be taken alongside other hair loss treatments such as minoxidil or finasteride. However, it’s essential to consult with a healthcare professional for personalized advice.
How long does it take to see results from NMN?
While individual results may vary, it can take several weeks to months of consistent NMN supplementation to notice potential benefits for hair growth.
Conclusion
NMN holds promise as a potential ally in the fight against hair loss and promoting regrowth. While more research is needed to establish its efficacy fully, its ability to enhance HDPC function, reduce inflammation, and combat oxidative stress makes it a valuable topic of interest for those concerned about hair health. As always, maintaining a healthy lifestyle, including a balanced diet and professional guidance, is essential for optimal hair growth outcomes. If you're experiencing hair loss or thinning, consider consulting with a professional at My Hair UK to explore the best treatment options tailored to your needs.
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